Journal article

Retinal hyperspectral imaging in the 5xFAD mouse model of Alzheimer's disease

Jeremiah KH Lim, Qiao-Xin Li, Tim Ryan, Phillip Bedggood, Andrew Metha, Algis J Vingrys, Bang Bui, Christine TO Nguyen

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2021

Abstract

Hyperspectral imaging of the retina has recently been posited as a potentially useful form of spectroscopy of amyloid-beta (Aβ) protein in the eyes of those with Alzheimer's disease (AD). The concept of using the retina as a biomarker for AD is an attractive one, as current screening tools for AD are either expensive or inaccessible. Recent studies have investigated hyperspectral imaging in Aβ models however these studies have been in younger mice. Here we characterised hyperspectral reflectance profile in 6 to 17 months old 5xFAD mice and compare this to Aβ in isolated preparations. Hyperspectral imaging was conducted across two preparations of Aβ using a custom built bench ophthalmoscope. ..

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Grants

Awarded by ARC Linkage grant


Funding Acknowledgements

C.N., B.B., A.V.: ARC Linkage grant LP160100126, C.N.: Melbourne Research Fellowship, Melbourne Neuroscience Institute Fellowship, Melbourne School of Health Sciences Seed funding JL: Guelma-Alexander Clinical Fellowship in Neuroscience 2019, Melbourne Neuroscience Institute Strategic Postgraduate Award (STRAPA).