Netrins: Evolutionarily Conserved Regulators of Epithelial Fusion and Closure in Development and Wound Healing
Vishal Chaturvedi, Michael J Murray
Cells Tissues Organs | KARGER | Published : 2021
Epithelial remodelling plays a crucial role during development. The ability of epithelial sheets to temporarily lose their integrity as they fuse with other epithelial sheets underpins events such as the closure of the neural tube and palate. During fusion, epithelial cells undergo some degree of epithelial-mesenchymal transition (EMT), whereby cells from opposing sheets dissolve existing cell-cell junctions, degrade the basement membrane, extend motile processes to contact each other, and then re-establish cell-cell junctions as they fuse. Similar events occur when an epithelium is wounded. Cells at the edge of the wound undergo a partial EMT and migrate towards each other to close the gap...View full abstract
Awarded by National Health and Medical Research Council
This work was supported by a University of Melbourne MRGSS grant and a National Health and Medical Research Council Project Grant (GNT1107123) to M.J.M.