Journal article
Fetal programming pathway from maternal mental health to infant cortisol functioning: The role of placental 11β-HSD2 mRNA expression
M Galbally, SJ Watson, M Lappas, ER de Kloet, E van Rossum, C Wyrwoll, P Mark, AJ Lewis
Psychoneuroendocrinology | Published : 2021
Abstract
Placental 11β-HSD2 has been a focus of research for understanding potential fetal programming associated with maternal emotional disorders. This study examined the pathway from antenatal mental health via placental 11β-HSD2 mRNA to cortisol regulation in the infant offspring. This study reports on data obtained from 236 participants in the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS). At term, placental tissue was collected within 30 min of birth from 52 participants meeting current criteria for a depressive disorder, and 184 control participants. Depressive disorders were diagnosed using the SCID-IV. In addition, antidepressant use, depressive and anxiety symptoms were measured in ..
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Awarded by Deakin University
Funding Acknowledgements
Funding This study is supported through the 2012 National Priority Founding Round of Beyondblue in a threeyear research grant (ID 519240) and a 2015 National Health and Medical Research Council (NHMRC) project grant for 5 years (APP1106823) . Financial support has also been obtained from the Academic Research and Development Grants, Mercy Health and Centre for Mental Health and WellBeing, Deakin University.