Journal article

Cracking the "Sugar Code": A Snapshot of N- and O-Glycosylation Pathways and Functions in Plants Cells

Richard Strasser, Georg Seifert, Monika S Doblin, Kim L Johnson, Colin Ruprecht, Fabian Pfrengle, Antony Bacic, Jose M Estevez



Glycosylation is a fundamental co-translational and/or post-translational modification process where an attachment of sugars onto either proteins or lipids can alter their biological function, subcellular location and modulate the development and physiology of an organism. Glycosylation is not a template driven process and as such produces a vastly larger array of glycan structures through combinatorial use of enzymes and of repeated common scaffolds and as a consequence it provides a huge expansion of both the proteome and lipidome. While the essential role of N- and O-glycan modifications on mammalian glycoproteins is already well documented, we are just starting to decode their biological..

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University of Melbourne Researchers


Awarded by Austrian Science Fund (FWF)

Awarded by German Research Council (DFG)

Awarded by Australia Research Council

Awarded by ANPCyT

Awarded by Fondo Nacional de Desarrollo Cientifico y Tecnologico

Funding Acknowledgements

This work was supported by grants from the Austrian Science Fund (FWF) P31920-B22 to RS and P32332-B to GS, the German Research Council (DFG) PF850/1-1 and PF850/7-1 to FP, the Australia Research Council to the ARC Centre of Excellence in Plant Cell Walls (CE1101007) to AB, MD, and KJ, and ANPCyT (PICT2016-0132 and PICT2017-0066), Fondo Nacional de Desarrollo Cientifico y Tecnologico (1200010), and Instituto Milenio iBio - Iniciativa Cientifica Milenio, MINECON to JE.