Journal article

Combined use of two separate but protective vaccine antigens provides protection against Taenia ovis infection in lambs in the presence of protective maternal antibody

GBL Harrison, DD Heath, CM Robinson, SB Lawrence, RP Dempster, CG Gauci, MW Lightowlers, MD Rickard

VACCINE | ELSEVIER SCI LTD | Published : 2021

Abstract

Three recombinant Taenia ovis antigens (To45, To16, To18) each induce protective immunity in lambs or ewes against infection with T. ovis metacestodes. The degree and duration of immunity were assessed in lambs born from vaccinated ewes. Treatment group sizes varied, typically not fewer than 5 animals per group. Ewes were immunised with one T. ovis recombinant protein prior to lambing and the degree and duration of passive immunity in their lambs was assessed by challenge infection up to 18 weeks. Lambs were fully protected up to 6 weeks of age but immunity waned from 6 to 12 weeks and there was no protection when lambs were challenged at 15 weeks. Immunisation of lambs with the homologous r..

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Grants

Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

This work was supported by Pitman-Moore NZ Ltd, AgResearch NZ and National Health and Medical Research Council, Australia, grant GTN1105448.