Combined use of two separate but protective vaccine antigens provides protection against Taenia ovis infection in lambs in the presence of protective maternal antibody
GBL Harrison, DD Heath, CM Robinson, SB Lawrence, RP Dempster, CG Gauci, MW Lightowlers, MD Rickard
VACCINE | ELSEVIER SCI LTD | Published : 2021
Three recombinant Taenia ovis antigens (To45, To16, To18) each induce protective immunity in lambs or ewes against infection with T. ovis metacestodes. The degree and duration of immunity were assessed in lambs born from vaccinated ewes. Treatment group sizes varied, typically not fewer than 5 animals per group. Ewes were immunised with one T. ovis recombinant protein prior to lambing and the degree and duration of passive immunity in their lambs was assessed by challenge infection up to 18 weeks. Lambs were fully protected up to 6 weeks of age but immunity waned from 6 to 12 weeks and there was no protection when lambs were challenged at 15 weeks. Immunisation of lambs with the homologous r..View full abstract
Awarded by National Health and Medical Research Council, Australia
This work was supported by Pitman-Moore NZ Ltd, AgResearch NZ and National Health and Medical Research Council, Australia, grant GTN1105448.