Journal article
Preface to the Special Issue “Presynaptic Dysfunction and Disease”
KJ Smillie, MA Cousin, SL Gordon
Journal of Neurochemistry | Published : 2021
DOI: 10.1111/jnc.15319
Abstract
The synapse is formed between a presynapse (which releases neurotransmitter) and the postsynapse (which transduces this chemical signal). Over the past decade, presynaptic dysfunction has emerged as a key mediator of a series of neurodevelopmental and neurodegenerative disorders. This special issue will highlight some of the important presynaptic molecules and mechanisms that are disrupted in these conditions and reveal potential routes for therapy.
Grants
Awarded by McMaster University
Funding Acknowledgements
This work was supported by an Ideas Grant from The National Health and Medical Research Council (NHMRC) of Australia (SLG, grant reference-GNT2003710), an Investigator Award from The Wellcome Trust (MAC, grant reference -204954), the Simons Foundation Autism Research Initiative (SFARI) to the Simons Initiative for the Developing Brain (MAC, grant reference-529805), and Cure Huntington's Disease Initiative (KJS and MAC, grant reference-A-14021). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.