Journal article

Analysis of morphological and neurochemical changes in subthalamic nucleus neurons in response to a unilateral 6-OHDA lesion of the substantia nigra in adult rats

Katayoun Sedaghat, Andrew L Gundlach, David Finkelstein



Background: Subthalamic nucleus (STN) neurons undergo changes in their pattern of activity and morphology during the clinical course of Parkinson's disease (PD). Striatal dopamine depletion and hyperactivity of neurons in the parafascicular nucleus (Pf) of the intralaminar thalamus are predicted to contribute to the STN changes. Objective: This study investigated possible morphological and neurochemical changes in STN neurons in a rat model of unilateral, nigral dopamine neuron loss, in relation to previously documented alterations in Pf neurons. Methods: Male Sprague-Dawley rats received a unilateral injection of 6-hydroxydopamine (6-OHDA) into the substantia nigra pars compacta (SNpc). Rat..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This research was supported by a project grant from the National Health and Medical Research Council (NHMRC) of Australia (1005988, ALG) and a grant from the Brain Foundation Australia (ALG). The funding sources had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or the decision to submit the article for publication.