Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group

B Lacas; A Carmel; C Landais; SJ Wong; L Licitra; JS Tobias; B Burtness; MG Ghi; EEW Cohen; C Grau; G Wolf; R Hitt; R Corvò; V Budach; S Kumar; SG Laskar; JJ Mazeron; LP Zhong; W Dobrowsky; P Ghadjar; C Fallai; B Zakotnik; A Sharma; RJ Bensadoun; MG Ruo Redda; S Racadot; G Fountzilas; D Brizel; P Rovea; A Argiris; ZT Nagy; JW Lee; C Fortpied; J Harris; J Bourhis; A Aupérin; P Blanchard; JP Pignon; DJ Adelstein; M Alfonsi; Y Belkacemi; V Bar-Ad; J Bernier; Bratland; G Calais; B Campbell; J Caudell; S Chabaud; E Chamorey; D Chaukar; KN Choi; O Choussy; L Collette; JJ Cruz; C Dani; E Dauzier; AA Forastiere; P Garaud; V Gregoire; A Hackshaw; E Haddad; BG Haffty; A Hansen; S Hayoz; JC Horiot; B Jeremic; TG Karrison; JA Langendijk; M Lapeyre; E Lartigau; T Leong; QT Le; PPY Lee; F Lewin; A Lin; A Lopes; S Mehta; J Moon; E Moyal; BV Occéan; P Olmi; R Orecchia; B O'Sullivan; J Overgaard; C Petit; H Quon; G Sanguineti; T Satar; J Simes; C Simon; C Sire; S Staar; C Stromberger; P Strojan; S Temam; D Thomson; A Timochenko; V Torri; V Tseroni; J Vermorken

Journal article

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group

B Lacas, A Carmel, C Landais, SJ Wong, L Licitra, JS Tobias, B Burtness, MG Ghi, EEW Cohen, C Grau, G Wolf, R Hitt, R Corvò, V Budach, S Kumar, SG Laskar, JJ Mazeron, LP Zhong, W Dobrowsky, P Ghadjar Show all

Radiotherapy and Oncology | Published : 2021

DOI: 10.1016/j.radonc.2021.01.013

Abstract

Background and purpose: The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results. Materials and methods: Published or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible. Individual patient data were collected and c..

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