Journal article

A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury

Rishabh Sharma, Akram Zamani, Larissa K Dill, Mujun Sun, Erskine Chu, Marcus J Robinson, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple

Journal of Neuroinflammation | BMC | Published : 2021

Abstract

BACKGROUND: Traumatic brain injury (TBI) is a major cause of disability in young children, yet the factors contributing to poor outcomes in this population are not well understood. TBI patients are highly susceptible to nosocomial infections, which are mostly acquired within the first week of hospitalization, and such infections may modify TBI pathobiology and recovery. In this study, we hypothesized that a peripheral immune challenge such as lipopolysaccharide (LPS)-mimicking a hospital-acquired infection-would worsen outcomes after experimental pediatric TBI, by perpetuating the inflammatory immune response. METHODS: Three-week-old male mice received either a moderate controlled cortical i..

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Grants

Funding Acknowledgements

This study was supported by funding from the National Health and Medical Research Council of Australia (NHMRC) in the form of fellowships to BDS, SRS, and TOB, with additional funding provided by Monash University.