Journal article

Learning deficit in cognitively normal APOE ε4 carriers with LOW β-amyloid.

Yen Ying Lim, Jenalle E Baker, Andrea Mills, Loren Bruns, Christopher Fowler, Jurgen Fripp, Stephanie R Rainey-Smith, David Ames, Colin L Masters, Paul Maruff

Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring | Published : 2021


Introduction: In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ-) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ- CNs. Methods: Aβ- CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT) over 6 days. Results: Aβ- ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non-carriers (d = 0.3). Rates of learning on the ORCA-LLT were significantly slower in Aβ- ε..

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