Journal article

Learning deficit in cognitively normal APOE epsilon 4 carriers with LOW beta-amyloid

Yen Ying Lim, Jenalle E Baker, Andrea Mills, Loren Bruns, Christopher Fowler, Jurgen Fripp, Stephanie R Rainey-Smith, David Ames, Colin L Masters, Paul Maruff



Introduction: In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ-) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ- CNs. Methods: Aβ- CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT) over 6 days. Results: Aβ- ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non-carriers (d = 0.3). Rates of learning on the ORCA-LLT were significantly slower in Aβ- ε..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

Funding for the AIBL study was provided in part by the study partners (Australian Commonwealth Scientific Industrial and Research Organization [CSIRO], Edith Cowan University [ECU], Mental Health Research Institute [MHRI], Alzheimer's Australia [AA], National Ageing Research Institute [NARI], Austin Health, CogState Ltd., Hollywood Private Hospital, Sir Charles Gardner Hospital). The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as ongoing funding from the Science and Industry Endowment Fund (SIEF).YYL reports grants from the National Health and Medical Research Council (GNT1111603, GNT1147465). Funding for the ORCA study was provided by the Dementia Australia Research Foundation and the VictorianMedical Research Acceleration Fund.