Journal article

Antibiotic Resistant Bloodstream Infections in Pediatric Patients Receiving Chemotherapy or Hematopoietic Stem Cell Transplant: Factors Associated with Development of Resistance, Intensive Care Admission and Mortality

Elio Castagnola, Francesca Bagnasco, Alessio Mesini, Philipp KA Agyeman, Roland A Ammann, Fabianne Carlesse, Maria Elena Santolaya de Pablo, Andreas H Groll, Gabrielle M Haeusler, Thomas Lehrnbecher, Arne Simon, Maria Rosaria D'Amico, Austin Duong, Evgeny A Idelevich, Marie Luckowitsch, Mariaclaudia Meli, Giuseppe Menna, Sasha Palmert, Giovanna Russo, Marco Sarno Show all

ANTIBIOTICS-BASEL | MDPI | Published : 2021

Abstract

Bloodstream infections (BSI) are a severe complication of antineoplastic chemotherapy or hematopoietic stem cell transplantation (HSCT), especially in the presence of antibiotic resistance (AR). A multinational, multicenter retrospective study in patients aged ≤ 18 years, treated with chemotherapy or HSCT from 2015 to 2017 was implemented to analyze AR among non-common skin commensals BSI. Risk factors associated with AR, intensive care unit (ICU) admission and mortality were analyzed by multilevel mixed effects or standard logistic regressions. A total of 1291 BSIs with 1379 strains were reported in 1031 patients. Among Gram-negatives more than 20% were resistant to ceftazidime, cefepime, p..

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Grants

Awarded by Ministero della Salute


Funding Acknowledgements

The study was partially supported by grants from IRCCS Istituto Giannina Gaslini, Genoa-Italy, and Ministero della Salute, Ricerca corrente 2011, Ricerca scientifica corrente 2011 MSALRC11 DEL.30/12.