Journal article

Prognosis of Severe Low-Flow, Low-Gradient Aortic Stenosis by Stroke Volume Index and Transvalvular Flow Rate

Jonathan Sen, Quan Huynh, Dion Stub, Christopher Neil, Thomas H Marwick

JACC Cardiovascular Imaging | ELSEVIER SCIENCE INC | Published : 2021

Abstract

OBJECTIVES: This study determined whether flow state classified by stroke volume index (SVi) or transvalvular flow rate (FR) improved risk stratification of all-cause mortality, hospitalization due to heart failure, and aortic valvular interventions for patients with severe aortic stenosis (AS). BACKGROUND: SVi is a widely accepted classification for flow state in severe low-flow, low-gradient (LFLG) AS. Recent studies suggest that FR more closely approximates true AS severity and provides more useful prognostication than SVi. METHODS: Patients with severe AS over a 7-year period were subclassified by echocardiographic parameters. LFLG-AS was defined as severe AS (aortic valve area index [AV..

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Grants

Awarded by National Health and Medical Research Council, Canberra


Awarded by National Heart Foundation of Australia


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This work has been supported in part by a partnership grant (1149692) from the National Health and Medical Research Council, Canberra. Dr. Sen was supported by scholarships from the National Heart Foundation of Australia (identification: 102578) , National Health and Medical Research Council of Australia (identification: 1191044) , Baker Heart and Diabetes Institute (Bright Sparks) , and the Australian Government Research Training Program. Dr. Stub is supported by a fellowship from the National Heart Foundation, Canberra. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.