Journal article

Lubricin as a tool for controlling adhesion in vivo and ex vivo

Clayton S Manasa, Saimon M Silva, Pauline E Desroches, Jessair Dennaoui, Mathew J Russo, Mingyu Han, Anita F Quigley, George W Greene, Robert MI Kapsa, Simon E Moulton



The ability to prevent or minimize the accumulation of unwanted biological materials on implantable medical devices is important in maintaining the long-term function of implants. To address this issue, there has been a focus on materials, both biological and synthetic, that have the potential to prevent device fouling. In this review, we introduce a glycoprotein called lubricin and report on its emergence as an effective antifouling coating material. We outline the versatility of lubricin coatings on different surfaces, describe the physical properties of its monolayer structures, and highlight its antifouling properties in improving implant compatibility as well as its use in treatment of ..

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Awarded by Australian Research Council

Funding Acknowledgements

We acknowledge the financial support from the Australian Research Council through the Discovery Project Program (No. DP180102287). The authors report no conflicts of interest in this work.