Role of microvascular dysfunction in left ventricular dysfunction in type 2 diabetes mellitus
Amera Halabi, Mark Nolan, Elizabeth Potter, Leah Wright, Atef Asham, Thomas H Marwick
JOURNAL OF DIABETES AND ITS COMPLICATIONS | ELSEVIER SCIENCE INC | Published : 2021
BACKGROUND: Although microvascular disease (mVD) has been linked to poor cardiovascular outcomes in diabetes mellitus, the contribution of mVD to diabetic cardiomyopathy (DC) is unexplored. We investigated whether LV systolic and diastolic dysfunction is associated with mVD in T2DM. METHODS: We recruited 32 asymptomatic patients with T2DM (age 71 ± 4 years, 31% females) from a community-based population. All underwent a comprehensive echocardiogram at baseline including assessment of global longitudinal strain (GLS) and diastolic function. Adenosine stress perfusion on cardiac magnetic resonance imaging (CMR) was performed in all patients. Coronary sinus flow (CSF) was measured offline at re..View full abstract
Awarded by Diabetes Australia
Supported in part by a grant from Diabetes Australia [grant ID Y19GMART] .