Journal article

Depletion of CD11c( ) dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth

Smriti M Krishna, Corey S Moran, Roby J Jose, Sharon Lazzaroni, Pacific Huynh, Jonathan Golledge



OBJECTIVE: The role of chronic inflammation in abdominal aortic aneurysm (AAA) is controversial. CD11c+ antigen-presenting cells (APCs) (dendritic cells (DCs)) have been reported in human AAA samples but their role is unclear. The effect of conditional depletion of CD11c+ cells on experimental AAA was investigated in the angiotensin II (AngII)-infused apolipoprotein E-deficient (ApoE-/-) mouse model. APPROACH: CD11c-diphtheria toxin (DT or D.tox) receptor (DTR), ovalbumin (OVA) fragment aa 140-386, and enhanced green fluorescent protein (eGFP)-ApoE-/- (CD11c.DOG.ApoE-/-) mice were generated and CD11c+ cell depletion achieved with D.tox injections (8 ng/g body weight, i.p., every-other-day). ..

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Awarded by National Health and Medical Research Council

Awarded by National Health and Medical Research Council, Australia

Funding Acknowledgements

This work was supported in part by the National Health and Medical Research Council [grant numbers 1098717, 1079369, 540403]; the Queensland Government; the Townsville Hospital Private Practice Trust; the Research Infrastructure Block Grant; the Medicine Incentive Grant; the School of Medicine, James Cook University; the Practitioner Fellowship from the National Health and Medical Research Council, Australia [grant number 1117061 (to J.G.)]; and the Senior Clinical Research Fellowship from the Queensland Government to J.G.]. The funding bodies played no role in generation of the data presented in this publication.