Plasma Low-density Lipoprotein Receptor-related Protein 1 Concentration is not Associated with Human Abdominal Aortic Aneurysm Presence
JV Moxon, R Behl-Gilhotra, SK Morton, SM Krishna, SW Seto, E Biros, M Nataatmadja, M West, PJ Walker, PE Norman, J Golledge
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY | W B SAUNDERS CO LTD | Published : 2015
OBJECTIVE/BACKGROUND: Recent genetic data suggest that a polymorphism of LRP1 is an independent risk factor for abdominal aortic aneurysm (AAA). The aims of this study were to assess whether plasma and aortic concentrations of low-density lipoprotein receptor-related protein 1 (LRP1) are associated with AAA, and to investigate the possible relevance of LRP1 to AAA pathophysiology. METHODS: Three analyses were conducted. First, plasma LRP1 concentrations were measured in community-dwelling men with and without AAA (n = 189 and n = 309, respectively) using enzyme-linked immunosorbent assay. Second, Western blotting analyses were employed to compare the expression of LRP1 protein in aortic biop..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by NHMRC, Australia
Awarded by Australian National Heart Foundation
This work was supported by grants from James Cook University; the Australian National Health and Medical Research Council (NHMRC: 1020955; 1022752; 1000967); The Townsville Hospital Private Practice Trust Fund; and the Queensland Government. J.G. holds a Practitioner Fellowship from the NHMRC, Australia (1019921) and a Senior Clinical Research Fellowship from the Queensland Government. S.W.S. is a recipient of fellowships from the NHMRC, Australia (1016349), and the Australian National Heart Foundation (PD12B6825). The funding bodies played no role in study design, data acquisition, analysis and interpretation, or manuscript preparation and submission.