Journal article

A diet enriched with tree nuts reduces severity of atherosclerosis but not abdominal aneurysm in angiotensin II-infused apolipoprotein E deficient mice

James Phie, Joseph V Moxon, Smriti M Krishna, Robert Kinobe, Susan K Morton, Jonathan Golledge

ATHEROSCLEROSIS | ELSEVIER IRELAND LTD | Published : 2018

Abstract

BACKGROUND AND AIMS: Diets enriched with tree nuts have been demonstrated to reduce the risk of atherosclerosis-related cardiovascular events. Abdominal aortic aneurysm (AAA) shares common risk factors with atherosclerosis and AAA patients commonly have atherosclerosis related cardiovascular events. AAA has some distinct pathological and clinical characteristics to those of atherosclerosis. No previous study has examined the effect of a diet enriched with tree nuts on experimental or clinical AAA. This study investigated the effect of a diet enriched with tree nuts on the development and severity of AAA within an experimental rodent model. METHODS: Male apolipoprotein E deficient mice were a..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council (NHMRC; 1098717), the Queensland Government and the James Cook University Graduate Research School. Jonathan Golledge holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1117061) and a Senior Clinical Research Fellowship from the Queensland Government. James Phie is supported by the Australian Postgraduate Award and the James Cook University College of Medicine and Dentistry Scholarship. Joseph V Moxon is supported by an Advance Queensland Fellowship from the Queensland Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.