Journal article

The relevance of epigenetics to occlusive cerebral and peripheral arterial disease

Smriti Murali Krishna, Alexandra Fay Trollope, Jonathan Golledge

CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2015

Abstract

Athero-thrombosis of the arteries supplying the brain and lower limb are the main causes of stroke and limb loss. New therapies are needed to improve the outcomes of athero-thrombosis. Recent evidence suggests a role for epigenetic changes in the development and progression of ischaemic injury due to atherosclerotic occlusion of peripheral arteries. DNA hypermethylation have been associated with cardiovascular diseases. Histone post-translational modifications have also been implicated in atherosclerosis. Oxidized low-density lipoprotein regulated pro-inflammatory gene expression within endothelial cells is controlled by phosphorylation/acetylation of histone H3 and acetylation of histone H4..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

This work is funded in part by the National Health and Medical Research Council [grant numbers 1021416, 1020955, 1003707 and 1000967]; the Queensland Government and the Townsville Hospital Private Practice Trust; a Practitioner Fellowship from the National Health and Medical Research Council, Australia [grant number 1019921 (to J.G.)]; and a Senior Clinical Research Fellowship from the Queensland Government. The funding bodies played no role in generation of the data presented in this publication.