Journal article

Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease

Diana Thomas Manapurathe, Joseph Vaughan Moxon, Smriti Murali Krishna, Sophie Rowbotham, Frank Quigley, Jason Jenkins, Michael Bourke, Bernard Bourke, Rhondda E Jones, Jonathan Golledge

JOURNAL OF THE AMERICAN HEART ASSOCIATION | WILEY | Published : 2019

Abstract

Background Hypertension is an important risk factor for cardiovascular events in patients with peripheral artery disease; however, optimal blood pressure targets for these patients are poorly defined. This study investigated the association between systolic blood pressure ( SBP ) and cardiovascular events in a prospectively recruited patient cohort with peripheral artery disease. Methods and Results A total of 2773 patients were included and were grouped according to SBP at recruitment (≤120 mm Hg, n=604; 121-140 mm Hg, n=1065; and >140 mm Hg, n=1104). Adjusted Cox proportional hazards analyses suggested that patients with SBP ≤120 mm Hg were at greater risk of having a major cardiovascular ..

View full abstract

Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

This study was supported by funding from the National Health and Medical Research Council (1063476 and 1000967) and the Queensland Government (Australia). Golledge holds a Practitioner Fellowship from the National Health and Medical Research Council (1117061) and a Senior Clinical Research Fellowship from the Queensland Government. Moxon is supported by an Advance Queensland Fellowship from the Queensland Government. Thomas Manapurathe is supported by a JCU (James Cook University) Postgraduate Research Scholarship and a JCU College of Medicine and Dentistry Scholarship.