Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis
James Phie, Smriti M Krishna, Joseph V Moxon, Safraz M Omer, Robert Kinobe, Jonathan Golledge
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2017
Diets rich in flavonoids have been reported to have beneficial effects in the primary prevention of cardiovascular events. There are limited data, however, on the cardiovascular benefits of purified flavonoids. The aim of this systematic review and meta-analysis was to examine the reported effects of isolated flavonoids on aortic atherosclerosis in a mouse model. Medline, Pubmed, Science direct and Web of Science were searched to identify studies which examined the effect of isolated flavonoids on aortic atherosclerosis in apolipoprotein E deficient mice. A meta-analysis was performed to determine the overall effect of the flavonoids, and sub-analyses were performed to compare the effects of..View full abstract
This work was supported by grants from the National Health and Medical Research Council (NHMRC), the Queensland Government and the Townsville Hospital Private Practice Trust. Jonathan Golledge holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia and a Senior Clinical Research Fellowship from the Queensland Government. JP is supported by the Australian Postgraduate Award and the James Cook University College of Medicine and Dentistry Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.