Journal article

Anionic nanoliposomes reduced atherosclerosis progression in Low Density Lipoprotein Receptor (LDLR) deficient mice fed a high fat diet

Smriti M Krishna, Joseph V Moxon, Roby J Jose, Jiaze Li, Amirhossein Sahebkar, Mahmoud R Jaafari, Mahdi Hatamipour, Dawie Liu, Jonathan Golledge

JOURNAL OF CELLULAR PHYSIOLOGY | WILEY | Published : 2018

Abstract

Atherosclerosis is a systemic disease characterized by the deposition of cholesterol and inflammatory cells within the arterial wall. Removal of cholesterol from the vessel wall may have an impact on the size and composition of atherosclerotic lesions. Anionic phospholipids or liposome vesicles composed of a lipid bilayer such as nanoliposomes have been suggested as treatments for dyslipidemia. In this study, we investigated the effect of anionic nanoliposomes on atherosclerosis in a mouse model. Low-density lipoprotein receptor knockout mice (Ldlr-/- ) were fed with an atherosclerosis promoting high fat and cholesterol (HFC) diet for 12 weeks. Anionic nanoliposomes including hydrogenated so..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

Mashhad University of Medical Sciences; James Cook University; National Health and Medical Research Council, Grant numbers: (1098717, 1079193, 1079369, 1000967); Queensland Government and the Mashhad University of Medical Sciences; National Health and Medical Research Council, Australia, Grant number: (1117061); Senior Clinical Research Fellowship from the Queensland Government