The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm
Jiaze Li, Smriti Murali Krishna, Jonathan Golledge
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2016
Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cell apoptosis, angiogenesis, oxidative stress and vascular remodeling are implicated in AAA pathogenesis. Kallistatin is a serine proteinase inhibitor, which has been shown to have a variety of functions, potentially relevant in AAA pathogenesis. Kallistatin has been reported to have inhibitory effects on tumor necrosis factor alpha (TNF-α) signaling induced oxidative stress and apoptosis. Kallistat..View full abstract
Awarded by National Health and Medical Research Council
Awarded by Medicine Incentive Grant, College of Medicine, James Cook University
Awarded by Jonathan Golledge holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia
This work is funded in part by grants from the National Health and Medical Research Council (1079369, 1098717), the Queensland Government, the Townsville Hospital Private Practice Trust, the Research Infrastructure Block Grant, and the Medicine Incentive Grant, College of Medicine, James Cook University (JCU-QLD-547271). Jonathan Golledge holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1019921) and a Senior Clinical Research Fellowship from the Queensland Government. The funding bodies played no role in generation of the data presented in this publication.