Journal article

Effect of blood pressure lowering medications on leg ischemia in peripheral artery disease patients: A meta-analysis of randomised controlled trials

Diana Thomas Manapurathe, Smriti Murali Krishna, Brittany Dewdney, Joseph Vaughan Moxon, Erik Biros, Jonathan Golledge

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2017

Abstract

BACKGROUND: It has been suggested that anti-hypertensive medications may worsen leg ischemia in peripheral artery disease (PAD) patients. We undertook a meta-analysis to assess the effect of anti-hypertensive medications on measures of leg ischemia including maximum walking distance (MWD), pain free walking distance (PFWD) and ankle brachial pressure index (ABPI). A meta-regression was performed to evaluate whether the effect of the anti-hypertensive medications on mean arterial pressure (MAP) was associated with changes in ABPI, MWD or PFWD. METHOD: A systematic literature search was performed to identify placebo controlled randomized control trials (RCT) testing anti-hypertensive medicatio..

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Grants

Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

This work was funded by grants from the National Health and Medical Research Council, the Queensland Government. JG holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1117061) and a Senior Clinical Research Fellowship from the Queensland Government. DTM is supported by JCU Post-graduate Research scholarship and JCU college of Medicine and Dentistry scholarship.