Journal article

Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis

Corey S Moran, Sai-Wang Seto, Smriti M Krishna, Surabhi Sharma, Roby J Jose, Erik Biros, Yutang Wang, Susan K Morton, Jonathan Golledge

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2017

Abstract

Intraluminal thrombus is a consistent feature of human abdominal aortic aneurysm (AAA). Coagulation factor Xa (FXa) catalyses FII to thrombin (FIIa). We examined the effect of FXa/FIIa inhibition on experimental aortic aneurysm in apolipoprotein E-deficient (ApoE-/-) mice infused with angiotensin II (AngII). The concentration of FXa within the supra-renal aorta (SRA) correlated positively with SRA diameter. Parenteral administration of enoxaparin (FXa/IIa inhibitor) and fondaparinux (FXa inhibitor) over 14 days reduced to severity of aortic aneurysm and atherosclerosis in AngII-infused ApoE-/- mice. Enteral administration of the FIIa inhibitor dabigatran had no significant effect. Aortic pro..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council, Australia


Awarded by Queensland Government Smart Futures Fellowship, Australia


Awarded by National Heart Foundation, Australia


Funding Acknowledgements

Funding from the National Institute of Health, National Health and Medical Research Council (1022752, 1021416, 1020955, 1003707 and 1000967) and Queensland Government supported this work. JG holds a Practitioner Fellowships from the National Health and Medical Research Council, Australia (1019921). JG holds a Senior Clinical Research Fellowship from the Queensland Government, Australia. CM previously held a Queensland Government Smart Futures Fellowship, Australia (ISF594). SS previously held Fellowships from the National Health and Medical Research Council, Australia (1016349) and the National Heart Foundation, Australia (PF12B6825). The funding bodies played no role in the production of this publication. The authors have no conflict of interests relevant to this article.