Journal article

The efficacy of extraembryonic stem cells in improving blood flow within animal models of lower limb ischaemia

Safraz Mohamed Omer, Smriti Murali Krishna, Jiaze Li, Joseph Vaughan Moxon, Vianne Nsengiyumva, Jonathan Golledge

HEART | BMJ PUBLISHING GROUP | Published : 2016

Abstract

BACKGROUND: Stem cell (SC) administration is a potential therapeutic strategy to improve blood supply in patients with peripheral artery disease (PAD). The aim of this systematic review and meta-analysis was to investigate the efficacy of extraembryonic tissue-derived SC (ETSC) in improving blood flow within animal models of hindlimb ischaemia (HLI). METHODS: PubMed, ScienceDirect and Web of Science were searched to identify studies which investigated ETSCs within animal HLI models. A meta-analysis was performed focusing on the effect of ETSCs on limb blood flow assessed by laser Doppler imaging using a random effects model. Methodological quality was assessed using a newly devised quality a..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

This work is funded in part by grants from the National Health and Medical Research Council (1079369, 1079193, 1063476, 1021416 and 1000967), the Queensland Government, the Townsville Hospital Private Practice Trust, the Research Infrastructure Block Grant and the Medicine Incentive Grant, School of Medicine, James Cook University. SMO is supported by the National Centre for Research Excellence in Peripheral Arterial Disease, Queensland Research Centre for Peripheral Vascular Diseases, James Cook University College of Medicine awards and James Cook University Postgraduate Research Scholarship funded by the Commonwealth Department of Education. JG holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1019921) and a Senior Clinical Research Fellowship from the Queensland Government.