Journal article

Epigenetics and Peripheral Artery Disease

Jonathan Golledge, Erik Biros, John Bingley, Vikram Iyer, Smriti M Krishna

CURRENT ATHEROSCLEROSIS REPORTS | CURRENT MEDICINE GROUP | Published : 2016

Abstract

The term epigenetics is usually used to describe inheritable changes in gene function which do not involve changes in the DNA sequence. These typically include non-coding RNAs, DNA methylation and histone modifications. Smoking and older age are recognised risk factors for peripheral artery diseases, such as occlusive lower limb artery disease and abdominal aortic aneurysm, and have been implicated in promoting epigenetic changes. This brief review describes studies that have associated epigenetic factors with peripheral artery diseases and investigations which have examined the effect of epigenetic modifications on the outcome of peripheral artery diseases in mouse models. Investigations ha..

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