Influence of apolipoprotein E, age and aortic site on calcium phosphate induced abdominal aortic aneurysm in mice
Yutang Wang, Smriti M Krishna, Joseph Moxon, Nguyen Dinh Tam, Roby J Jose, Hongyou Yu, Jonathan Golledge
ATHEROSCLEROSIS | ELSEVIER IRELAND LTD | Published : 2014
OBJECTIVE: To assess relevant features of abdominal aortic aneurysms (AAA) induced by calcium phosphate within a mouse model. Specifically we investigated: (1) whether apolipoprotein E deficiency and older age promoted AAA formation, and (2) whether the local application of calcium phosphate affected the size of distant aortic segments. METHODS: AAA was induced by application of calcium phosphate to the infra-renal aortas of 3 and 7 month old male mice. AAA induction was assessed by calculating expansion of the infra-renal aortic diameter over 1-4 weeks. Aortic samples were assessed to quantify calcification, macrophages infiltration, elastic lamellar degradation and apoptosis. Blood pressur..View full abstract
Awarded by National Health and Medical Research Council
This work is funded by grants from the National Health and Medical Research Council (grants 1021416, 1003707 and 1000967), the Office of Health and Medical Research and the Townsville Hospital Private Practice Trust. JG holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1019921) and a Senior Clinical Research Fellowship from the Queensland Government. The funding bodies played no role in generation of the data presented in this publication.