Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
Smriti Murali Krishna, Susan K Morton, Jiaze Li, Jonathan Golledge
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2020
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in older adults. In clinical practice, the most established predictor of AAA rupture is maximum AAA diameter. Aortic diameter is commonly used to assess AAA severity in mouse models studies. AAA rupture occurs when the stress (force per unit area) on the aneurysm wall exceeds wall strength. Previous research suggests that aortic wall structure and strength, biomechanical forces on the aorta and cellular and proteolytic composition of the AAA wall influence the risk of AAA rupture. Mouse models offer an opportunity to study the association of these factors with AAA rupture in a way not currently possible in patients. Such ..View full abstract
Awarded by National Health and Medical Research Council
Awarded by National Health and Medical Research Council, Australia
This work is funded in part by grants from the National Health and Medical Research Council (1079369, 1079193 and 1098717), the Queensland Government and The College of Medicine, James Cook University. JG holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1117061) and a Senior Clinical Research Fellowship from the Queensland Government. The funding bodies played no role in generation of the data presented in this publication.