Journal article

Genetic and epigenetic mechanisms and their possible role in abdominal aortic aneurysm

Smriti M Krishna, Anthony E Dear, Paul E Norman, Jonathan Golledge

ATHEROSCLEROSIS | ELSEVIER IRELAND LTD | Published : 2010

Abstract

Abdominal aortic aneurysm (AAA) is a common disease associated with significant cardiovascular morbidity and mortality. The pathogenesis of AAA is poorly defined, making targeting of new therapies problematic. Current evidence favours an interaction of multiple environmental and genetic factors in the initiation and progression of AAA. Epigenetics is the term used to define the properties of the genome that are not explained by the primary sequence, but are due to the modifications of DNA and/or associated proteins. Previous research indicates the association of gene specific promoter DNA hyper-methylation and global DNA hypo-methylation with atherosclerosis. Evidence also suggests an import..

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Grants

Awarded by National Institute of Health, USA


Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council, Australia


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

Work carried out by the research team is funded by grants from the National Institute of Health, USA [RO1 HL080010]; The Townsville Hospital Private Practice Fund; and The National Health and Medical Research Council [project grants 540403, 540404 and 540405]. JG and PEN hold Practitioner Fellowships from the National Health and Medical Research Council, Australia [431503,458505].