Journal article

The calcium chloride-induced rodent model of abdominal aortic aneurysm

Yutang Wang, Smriti Krishna, Jonathan Golledge

ATHEROSCLEROSIS | ELSEVIER IRELAND LTD | Published : 2013

Abstract

Abdominal aortic aneurysm (AAA) affects ∼5% men aged over 65 years and is an important cause of death in this population. Research into AAA pathogenesis has been fuelled by the need to identify new diagnostic biomarkers and therapeutic targets for this disease. One animal model of AAA involves peri-vascular application of calcium chloride (CaCl(2)) onto the infra-renal aorta of mice and rats to induce extracellular matrix remodelling. Twenty-three studies assessing CaCl(2)-induced AAA and six studies assessing AAA induced by a modified CaCl(2) method were identified. In the current report the preparation and pathological features of this AAA model are discussed. We also compared this animal ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

This work is funded by grants from the National Health and Medical Research Council (540404, 1021416) and the BUPA Foundation. JG holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1019921) and a Senior Clinical Research Fellowship from the Queensland Government.