Transforming growth factor-beta and abdominal aortic aneurysms
Yutang Wang, Smriti Krishna, Philip J Walker, Paul Norman, Jonathan Golledge
CARDIOVASCULAR PATHOLOGY | ELSEVIER SCIENCE INC | Published : 2013
Abdominal aortic aneurysms (AAAs) are common problems in aged people which can be associated with severe complications including aortic rupture and death. Transforming growth factor-β (TGFβ) has been implicated as causative in the development of thoracic aortic aneurysms (TAAs). In contrast, current evidence suggests TGFβ inhibits AAA development. Polymorphisms in the TGFβ signaling components are associated with AAA in some human population studies. In experimental animals TGFβ protects against AAA formation, progression and rupture. In animal models of AAA TGFβ decreases aortic inflammatory cell infiltration, extracellular matrix degradation, and vascular smooth muscle cell apoptosis, all ..View full abstract
Awarded by National Health and Medical Research Council
Awarded by National Health and Medical Research Council, Australia
This work is funded by grants from the National Health and Medical Research Council (540404, 1021416) and the BUPA Foundation. J.G. holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia (1019921), and a Senior Clinical Research Fellowship from the Queensland Government.