Journal article

Signaling Defects and Functional Impairment in T-Cells from Cervical Cancer Patients

Vino T Cheriyan, Smriti M Krishna, Aswin Kumar, Puthuveetil Govindan Jayaprakash, Prabha Balaram

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | MARY ANN LIEBERT, INC | Published : 2009

Abstract

The ability of T-lymphocytes to recognize antigens and transduce signals to the nucleus successfully is a key component in the initiation and maintenance of an immune response. The present study addressed the expression status of the signal-transducing proteins in relation to the immune impairment in cervical cancer patients. Immune response was measured by evaluating lymphocyte subpopulations CD3(+), CD4(+), and CD8(+), using flowcytometry, natural killer cell activity, using the single-cell cytotoxicity assay, lymphocyte function, using mitogenic response to PHA and T-cell activation following anti-CD3 stimulation, and production of IL-2. Expression of the T-cell signal transduction protei..

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