Signaling Defects and Functional Impairment in T-Cells from Cervical Cancer Patients
Vino T Cheriyan, Smriti M Krishna, Aswin Kumar, Puthuveetil Govindan Jayaprakash, Prabha Balaram
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | MARY ANN LIEBERT, INC | Published : 2009
The ability of T-lymphocytes to recognize antigens and transduce signals to the nucleus successfully is a key component in the initiation and maintenance of an immune response. The present study addressed the expression status of the signal-transducing proteins in relation to the immune impairment in cervical cancer patients. Immune response was measured by evaluating lymphocyte subpopulations CD3(+), CD4(+), and CD8(+), using flowcytometry, natural killer cell activity, using the single-cell cytotoxicity assay, lymphocyte function, using mitogenic response to PHA and T-cell activation following anti-CD3 stimulation, and production of IL-2. Expression of the T-cell signal transduction protei..View full abstract
The authors thank the Kerala State Council for Science, Technology, and Environment committee (KSCSTE in Trivandrum) of India for their financial support for the project and also wish to acknowledge Tata Memorial Trust for the fellowship offered to SMK to carry out the project.