Journal article

Association between serum interleukin-6 and frailty in older men: cross-sectional data

Monica C Tembo, Kara L Holloway-Kew, Chiara C Bortolasci, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco

EUROPEAN GERIATRIC MEDICINE | SPRINGER | Published : 2021

Abstract

PURPOSE: To investigate the association between serum interleukin-6 (IL-6) and frailty. METHODS: Participants were 581 men aged 60-90 yr (median (IQR): 74 yr (67-83 yr)) from the Geelong Osteoporosis Study. Tallies of ≥ 3, 1-2 and 0 for weight loss/exhaustion/physical-inactivity/slowness/weakness indicated frailty, pre-frailty and robustness, respectively. Anthropometry, lower-limb muscle strength and physical performance were measured and health behaviours self-reported. Serum IL-6 was measured using an enzyme-linked immunosorbent assay and log-transformed (ln-IL-6). Total antioxidant capacity (TAC) was also measured using quantitative colorimetric determination. Multivariable ordinal logis..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC Career Development Fellowship


Awarded by National Health and Medical Research Council (NHMRC) of Australia Career Development Fellowship


Awarded by NHMRC Investigator grant


Funding Acknowledgements

The Geelong Osteoporosis Study (GOS) was funded by the National Health and Medical Research Council (NHMRC) of Australia (projects 299831, 628582). The funding organisation played no role in the design or conduct of the study, in the collection, management, analysis and interpretation of the data, nor in the preparation, review and approval of the manuscript. MCT was supported by Deakin Postgraduate Scholarships, KLH-K and CCB were supported by Alfred Deakin Postdoctoral Research Fellowships; SLB-O was supported by a NHMRC Career Development Fellowship (1107510) and LJW is supported by a National Health and Medical Research Council (NHMRC) of Australia Career Development Fellowship (1064272) and a NHMRC Investigator grant (1174060).