Processed foods drive intestinal barrier permeability and microvascular diseases.
Matthew Snelson, Sih Min Tan, Rachel E Clarke, Cassandra de Pasquale, Vicki Thallas-Bonke, Tuong-Vi Nguyen, Sally A Penfold, Brooke E Harcourt, Karly C Sourris, Runa S Lindblom, Mark Ziemann, David Steer, Assam El-Osta, Michael J Davies, Leigh Donnellan, Permal Deo, Nicole J Kellow, Mark E Cooper, Trent M Woodruff, Charles R Mackay Show all
Science Advances | Published : 2021
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of CKD. Inhibition of the advanced glycation pathway, which generates Maillard reaction products within foods upon thermal processing, reversed kidney injury. Consequently, a processed diet leads to innate immune complement activation and local kidney inflammation and injury via the potent proinflammatory effector molecule complement 5a (C5a). In a mouse model of diabetes, a high resist..View full abstract