Journal article

Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

Ben J Gu, Xin Huang, Pavan K Avula, Emily Caruso, Candace Drysdale, Kirstan A Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L Masters, James S Wiley, Robyn H Guymer, Erica L Fletcher

Frontiers in Medicine | FRONTIERS MEDIA SA | Published : 2021

Abstract

Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evaluated peripheral blood monocyte phagocytic function at various stages of AMD and in aged matched control participants. Real-time tri-color flow cytometry was used to quantify phagocytic function of peripheral blood monocyte subsets (non-classic, intermediate and classic) isolated from subjects with intermediate or late AMD and compared with age matched healthy controls. Assessment of phagocytic function of monocytes isolated from those with and without reticular pseudodrusen was also made, and the effect of glatiramer acetate on phagocytic function assessed. Phagoc..

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Grants

Awarded by ARC Future Fellowship


Awarded by NHMRC


Awarded by BrightFocus Foundation Project Grant


Funding Acknowledgements

This work was supported by ARC Future Fellowship (BG, FT120100581) and NHMRC Project Grant (1048082, 1061419, 1120095, and 110178 to RG, EF, and BG), Principal Research Fellowship (RG, 1103013), Macular Disease Foundation Australia Project Grant (EF, BG, RG, and KV), Macular Society Grant USA (2015), BrightFocus Foundation Project Grant (M2016061), and the Victorian Government's Operational Infrastructure Support Grant to the Florey Institute and Center for Eye research Australia.