Journal article

Timing of primary syphilis treatment and impact on the development of treponemal antibodies: a cross-sectional clinic-based study.

Janet M Towns, David E Leslie, Ian Denham, Francesca Azzato, Theo Karapanagiotidis, Deborah A Williamson, Stephen R Graves, Christopher K Fairley, Melanie Bissessor, Eric PF Chow, Lei Zhang, Marcus Y Chen

Sex Transm Infect | Published : 2021

Abstract

BACKGROUND: Serology is negative in a proportion of primary syphilis cases where Treponema pallidum PCR testing is positive. We aimed to identify discordant, T. pallidum PCR-positive, serology-negative primary syphilis cases and any clinical or laboratory factors associated with failure to subsequently seroconvert. METHODS: Serodiscordant primary syphilis cases that were T. pallidum PCR-positive and serology-negative (including rapid plasma reagin, T. pallidum particle agglutination, T. pallidum enzyme immunoassay or T. pallidum chemiluminescence assay) were identified from the Melbourne Sexual Health Centre electronic records between April 2011 and December 2019. Clinical and laboratory ass..

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Grants

Awarded by Australian NHMRC Emerging Leadership Investigator Grant


Awarded by Royal Australasian College of Physicians Foundation Research Entry Scholarship


Awarded by National Health and Medical Research Council (NHMRC) Leadership Investigator Grant


Awarded by Monash University Research Training Program Stipend