Journal article

Atypical Antipsychotics Augmentation in Patients with Depressive Disorder and Risk of Subsequent Dementia: A Nationwide Population-Based Cohort Study

Jaehyun Kim, Tae Hyon Ha, Kiwon Kim, Eun-Mi Lee, Hyekyeong Kim, Doh Kwan Kim, Hong-Hee Won, Matthew Lewis, Hyewon Lee, Woojae Myung

JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2021

Abstract

BACKGROUND: While atypical antipsychotic medications are widely used for treating depressive disorders, their long-term effects on the risk of subsequent dementia have not been studied adequately. OBJECTIVE: To investigate whether the risk of dementia differs according to the use of atypical antipsychotic drugs, and compare the effects of antipsychotic agents on dementia risk in individuals with late-life depressive disorders. METHODS: A nationwide population-based retrospective cohort study was conducted using data from the National Health Insurance Service-Senior Cohort of South Korea. Atypical antipsychotic dosages were standardized using a defined daily dose, and the cumulative dosage wa..

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University of Melbourne Researchers

Grants

Awarded by National Research Foundation of Korea (NRF) of Korea - Ministry of Science and ICT (Information and Communication Technologies), South Korea


Awarded by Basic Science Research Program through the NRF of Korea - Ministry of Education, South Korea


Awarded by Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea


Awarded by National Research Foundation ofKorea Grant - Korean Government


Awarded by Korean NHIS


Funding Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) of Korea Grant funded by the Ministry of Science and ICT (Information and Communication Technologies), South Korea [grant number NRF-2018R1C1B6001708; W Myung], and by the Basic Science Research Program through the NRF of Korea, funded by the Ministry of Education, South Korea [grant number NRF-2018R1D1A1B07049034; H Lee]. This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0416; W Myung). This work was also supported by the National Research Foundation ofKorea Grant funded by the Korean Government (NRF2012S1A6A3A01033504; W Myung). This work was also supported by ALVOGEN KOREA. This study used NHIS data (NHIS-2019-2-275) from the Korean NHIS. The funding source had no involvement in the study design; the collection, analysis, and interpretation of data; in the writing of the paper; and in the decision to submit the article for publication.