Journal article

Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies potential targets of allele-specific immunity to clinical malaria

Zalak Shah, Myo Naung, Kara Moser, Matthew Adams, Andrea Buchwald, Ankit Dwivedi, Amed Ouattara, Karl Seydel, Don Mathanga, Alyssa Barry, David Serre, Miriam Laufer, Joana Silva, Shannon Takala-Harrison

Published : 2020

Abstract

Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. This immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode likely targets of naturally a..

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University of Melbourne Researchers