Journal article

Urinary and renal oxygenation during dexmedetomidine infusion in critically ill adults with mechanistic insights from an ovine model

Mark P Plummer, Yugeesh R Lankadeva, Mark E Finnis, Anatole Harrois, Charlie Harding, Rachel M Peiris, Nobuki Okazaki, Clive N May, Roger G Evans, Christopher M Macisaac, Deborah Barge, Rinaldo Bellomo, Adam M Deane



PURPOSE: Examine effects of dexmedetomidine on bladder urinary oxygen tension (PuO2) in critically ill patients and delineate mechanisms in an ovine model. MATERIALS AND METHODS: In 12 critically ill patients: oxygen-sensing probe inserted in the bladder catheter and dexmedetomidine infusion at a mean (SD) rate of 0.9 ± 0.3 μg/kg/h for 24-h. In 9 sheep: implantation of flow probes around the renal and pulmonary arteries, and oxygen-sensing probes in the renal cortex, renal medulla and bladder catheter; dexmedetomidine infusion at 0.5 μg/kg/h for 4-h and 1.0 μg/kg/h for 4-h then 16 h observation. RESULTS: In patients, dexmedetomidine decreased bladder PuO2at 2 (-Δ11 (95% CI 7-16)mmHg), 8 (-Δ ..

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Awarded by National Health and Medical Research Council of Australia

Awarded by National Heart Foundation of Australia (NHF)

Funding Acknowledgements

Author RB has received fees for expert testimony fromPfizer. Author RGE has received consulting fees from Medtronic Inc. The work at the Florey Institute of Neuroscience and Mental Health was supported by the National Health and Medical Research Council of Australia (GNT1188514) and the Victorian Government Operational Infrastructure Support Grant. YRL was supported by a Future Leader Fellowship by the National Heart Foundation of Australia (NHF, 101853). The remaining authors have disclosed that they do not have any conflicts of interest.