Journal article
Prenatal Testosterone Associates with Blood Pressure in Young Adults: A Prospective Cohort Study
C Le-Ha, LJ Beilin, S Burrows, JA Keelan, M Hickey, TA Mori
Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
Open access
Abstract
Preclinical evidence suggests that adult blood pressure (BP) may be modified by the prenatal endocrine environment. Specifically, in several animal models, higher prenatal testosterone exposure increases the risk of hypertension in later life. We investigated the prospective association between prenatal testosterone levels (as measured in umbilical cord blood) and BP at 20 to 27 years in 434 participants from the Raine Study. As expected, median bioavailable testosterone, the fraction of total testosterone either free or bound to serum albumin, was higher in males than females (0.12 [Q1-Q3, 0.09-0.19] versus 0.07 [Q1-Q3, 0.05-0.1] nmol/L; P<0.001). Mean (SD) systolic BP was 122.9 (±12.3) and..
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Awarded by Royal Perth Hospital Medical Research Foundation
Funding Acknowledgements
C. Le-Ha was supported by a Springboard Grant from the RPH Research Foundation. We acknowledge the National Health and Medical Research Council (NHMRC) for long-term contribution to funding the Raine Study. The Raine Medical Research Foundation, the University of Western Australia, Curtin University, Telethon Kids Institute, the Women's and Infant's Research Foundation, Edith Cowan University, Murdoch University, and the University of Notre Dame Australia are acknowledged for their support and funding of the core management of the Raine Study. The 27-year review of the Raine cohort was funded by NHMRC project grants 1102106 and 1109057, and the Royal Perth Hospital Research Foundation.