Journal article

The safety of BCG revaccination: A systematic review

Samantha Bannister, Eva Sudbury, Paola Villanueva, Kirsten Perrett, Nigel Curtis

VACCINE | ELSEVIER SCI LTD | Published : 2021

Abstract

INTRODUCTION: Revaccination with Bacillus Calmette-Guérin (BCG) vaccine is not generally recommended due to a lack of proven efficacy of repeat doses for protection against tuberculosis. However, there is a growing interest in the use of BCG vaccine for its 'off-target' effects which might involve revaccination. We did a systematic review of the safety of BCG revaccination. METHODS: MEDLINE (1946 to March 2020) and the BCG World Atlas (updated 2017) were searched, limiting to studies of BCG administration by the intradermal or percutaneous route. Adverse events as well as patient and vaccine characteristics were reviewed. RESULTS: The search identified 388 articles, of which 24 met the inclu..

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