Complete pathological response in rectal cancer utilising novel treatment strategies for neo-adjuvant therapy: A systematic review.
K Wilson, M Flood, V Narasimhan, T Pham, S Warrier, R Ramsay, M Michael, A Heriot
Eur J Surg Oncol | Published : 2021
BACKGROUND: Locally advanced rectal cancer is routinely treated with neo-adjuvant long course chemoradiotherapy or short course radiotherapy, followed by total mesorectal excision. Not all patients respond to this treatment and there has been an emergence of novel treatment strategies designed to improve outcomes for these patients. This systematic review aims to assess the current novel neo-adjuvant treatment strategies being utilised in the treatment of patients with rectal cancer and how these impact pathological complete response (pCR) rates. METHODS: A systematic review of the literature was performed to evaluate pathological response in patients with rectal cancer receiving novel neo-a..View full abstract