Journal article

Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Martha Alemayehu Menberu, Sha Liu, Clare Cooksley, Andrew James Hayes, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde

PATHOGENS | MDPI | Published : 2021

Abstract

Corynebacterium accolens is the predominant species of the healthy human nasal microbiota, and its relative abundance is decreased in the context of chronic rhinosinusitis (CRS). This study aimed to evaluate the antimicrobial potential of C. accolens isolated from a healthy human nasal cavity against planktonic and biofilm growth of Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA) clinical isolates (CIs) from CRS patients. Nasal swabs from twenty non-CRS control subjects were screened for the presence of C. accolens using microbiological and molecular techniques. C. accolens CIs and their culture supernatants were tested for their antimicrobial activity against ei..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

This research was supported from Garnett Passe and Rodney Williams Memorial Foundation Conjoint Grant awarded to A.J.P. and S.V; and the University of Adelaide (International Scholarship) to M.A.M.