Journal article

Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement

Steffen Schmitz-Valckenberg, Zhichao Wu, Maximilian Pfau, Barbara Blodi, Frank G Holz, Petrus Chang, Glenn J Jaffe, Sandra Liakopoulos, Srinivas R Sadda, Giovanni Staurenghi, Robyn H Guymer

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2021

Abstract

PURPOSE: To determine the interreader agreement for incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA) and their related features in age-related macular degeneration (AMD). DESIGN: Interreader agreement study. PARTICIPANTS: Twelve readers from 6 reading centers. METHODS: After formal training, readers qualitatively assessed 60 OCT B-scans from 60 eyes with AMD for 9 individual features associated with early atrophy and performed 7 different annotations to quantify the spatial extent of OCT features within regions of interest. The qualitative and quantitative features were used to derive the presence of iRORA and cR..

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Grants

Awarded by Federal Ministry of Education and Research of Germany (BMBF)


Awarded by National Health & Medical Research Council of Australia


Awarded by German Research Foundation (DFG)


Funding Acknowledgements

Supported in part by an Unrestricted Grant from Research to Prevent Blindness, New York, NY, tothe Department of Ophthalmology & Visual Sciences, University of Utah, Federal Ministry of Education andResearch of Germany (BMBF), Scholarship FKZ 13N10349 and a National Health & Medical ResearchCouncil of Australia fellowship grant no.: GNT1103013 [RHG], the German Research Foundation (DFG) grantno.: PF950/1-1 [MP]