Journal article

Senescence in tissue samples of humans with age-related diseases: A systematic review

Camilla SL Tuttle, Suzanne WM Luesken, Mariette EC Waaijer, Andrea B Maier

AGEING RESEARCH REVIEWS | ELSEVIER IRELAND LTD | Published : 2021

Abstract

BACKGROUND: Higher numbers of senescent cells have been implicated in age-related disease pathologies. However, whether different diseases have different senescent phenotypes is unknown. Here we provide a systematic overview of the current available evidence of senescent cells in age-related diseases pathologies in humans and the markers currently used to detect senescence levels in humans. METHODS: PubMed, Web of Science and EMBASE were systematically searched from inception to the 29th of September 2019, using keywords related to 'senescence', 'age-related diseases' and 'biopsies'. RESULTS: In total 12,590 articles were retrieved of which 103 articles were included in this review. The role..

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