A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis-Why and How?
Timothy D Hewitson, Edward R Smith
Frontiers in Physiology | FRONTIERS MEDIA SA | Published : 2021
Chronic Kidney Disease (CKD) is characterized by organ remodeling and fibrosis due to failed wound repair after on-going or severe injury. Key to this process is the continued activation and presence of matrix-producing renal fibroblasts. In cancer, metabolic alterations help cells to acquire and maintain a malignant phenotype. More recent evidence suggests that something similar occurs in the fibroblast during activation. To support these functions, pro-fibrotic signals released in response to injury induce metabolic reprograming to meet the high bioenergetic and biosynthetic demands of the (myo)fibroblastic phenotype. Fibrogenic signals such as TGF-β1 trigger a rewiring of cellular metabol..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
The work was supported by a specific project grant from the National Health and Medical Research Council (NHMRC) of Australia (APP1078694).