Journal article
Effect of a medium cut-off dialyzer on protein-bound uremic toxins and mineral metabolism markers in patients on hemodialysis
MK Tiong, R Krishnasamy, ER Smith, CA Hutchison, EG Ryan, EM Pascoe, CM Hawley, TD Hewitson, MJ Jardine, MA Roberts, Y Cho, MG Wong, A Heath, CL Nelson, S Sen, PF Mount, LA Vergara, PA Paul-Brent, DW Johnson, ND Toussaint
Hemodialysis International | WILEY | Published : 2021
DOI: 10.1111/hdi.12924
Abstract
Introduction: Hemodialysis (HD) with medium cut-off (MCO) dialyzers may expand molecular clearance, predominantly larger middle molecules (molecular weight 25–60 kDa). However, the impact of MCO dialyzers on long-term clearance of various other components of the uremic milieu is unknown. The tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HemoDialysis patients (REMOVAL-HD) provided an opportunity to assess the effect of MCO dialyzers on protein-bound uremic toxins and novel markers of mineral metabolism. Methods: This exploratory sub-study of REMOVAL-HD evaluated changes in protein-bound solutes (total and free indoxyl sulfate [IS] and p-cresyl sulfate [P..
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Funding Acknowledgements
Baxter Investigator Initiated Research Grant; Kidney Health Australia (via the AKTN); RMH Home Lottery Project Grant