Expression Profile of Stemness Markers CD138, Nestin and Alpha-SMA in Ameloblastic Tumours
Callisthenis Yiannis, Massimo Mascolo, Michele Davide Mignogna, Silvia Varricchio, Valentina Natella, Gaetano De Rosa, Roberto Lo Giudice, Cosimo Galletti, Rita Paolini, Antonio Celentano
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | MDPI | Published : 2021
Ameloblastic carcinoma is a rare malignant odontogenic neoplasm with a poor prognosis. It can arise de novo or from a pre-existing ameloblastoma. Research into stemness marker expression in ameloblastic tumours is lacking. This study aimed to explore the immunohistochemical expression of stemness markers nestin, CD138, and alpha-smooth muscle actin (alpha-SMA) for the characterisation of ameloblastic tumours. Six cases of ameloblastoma and four cases of ameloblastic carcinoma were assessed, including one case of ameloblastic carcinoma arising from desmoplastic ameloblastoma. In all tumour samples, CD138 was positive, whilst alpha-SMA was negative. Nestin was negative in all but one tumour sa..View full abstract
The authors gratefully acknowledge the support of the Melbourne Dental School, The University of Melbourne, and of the University "Federico II" of Naples, Naples, Italy.