Journal article

Preventive interventions for individuals at ultra high risk for psychosis: An updated and extended meta-analysis

Cristina Mei, Mark van der Gaag, Barnaby Nelson, Filip Smit, Hok Pan Yuen, Maximus Berger, Marija Krcmar, Paul French, G Paul Amminger, Andreas Bechdolf, Pim Cuijpers, Alison R Yung, Patrick D McGorry



Intervention at the earliest illness stage, in ultra or clinical high-risk individuals, or indicated prevention, currently represents the most promising strategy to ameliorate, delay or prevent psychosis. We review the current state of evidence and conduct a broad-spectrum meta-analysis of various outcomes: transition to psychosis, attenuated positive and negative psychotic symptoms, mania, depression, anxiety, general psychopathology, symptom-related distress, functioning, quality of life, and treatment acceptability. 26 randomized controlled trials were included. Meta-analytically pooled interventions reduced transition rate (risk ratio [RR] = 0.57, 95%CI 0.41-0.81) and attenuated positive..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

PDM is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1155508). BN is supported by an NHMRC Senior Research Fellowship (1137687). The funding source had no role in the study design, data collection, analysis and interpretation, writing of the manuscript, and in the decision to submit the article for publication.